Randomized Double-Blind Clinical Trial of Eutectic Mixture of Local Anesthetic Creams in Reducing Pain During Hysterosalpingography

AUTHORS

Mojgan Kalantari 1 , Shahrzad Zadeh Modares 2 , firoozeh ahmadi 3 , * , Vajihe Hazari 4 , Hadieh Haghighi 3 , Mohammad Chehrazi 5 , Melika Razaghi 6

1 Department of Radiology, Mahdieh Hospital, Infertility and Reproductive Health Research Center (IRHRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Infertility and Reproductive Health Research Center (IRHRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran

3 Department of Reproductive Imaging at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran

4 Mahdieh Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

5 Department of Epidemiology and Reproductive Health at Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran

6 Department of Endodontics, Shahed Dental University, Tehran, Iran

How to Cite: Kalantari M, Zadeh Modares S, ahmadi F, Hazari V, Haghighi H, et al. Randomized Double-Blind Clinical Trial of Eutectic Mixture of Local Anesthetic Creams in Reducing Pain During Hysterosalpingography, Iran J Radiol. 2014 ; 11(4):e93650. doi: 10.5812/iranjradiol.10513.

ARTICLE INFORMATION

Iranian Journal of Radiology: 11 (4); e93650
Published Online: September 23, 2014
Article Type: Research Article
Received: May 14, 2019
Accepted: August 07, 2013
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Abstract

Background: Hysterosalpingography (HSG) is considered as a primary test in infertility work up worldwide due to its reliability in evaluating abnormalities related to the uterus and fallopian tubes.

Objectives: To assess the efficacy of applying eutectic mixture of local anesthetics (lidocaine-prilocaine cream) (EMLA) on the uterine cervix in reducing pain during HSG.

Patients and Methods: Eighty patients undergoing HSG as part of infertility evaluation were randomly allocated to groups receiving either EMLA (N = 40) or placebo cream (N = 40) in a double-blinded prospective study. Fifteen minutes before HSG, 5 grams of 5% cream was applied to the uterine cervix using a cervical applicator. The degree of pain experienced by the patient was evaluated during and after HSG at five predefined steps on a visual analogue scale (VAS).

Results: There was no significant difference in the efficacy between EMLA and placebo creams in pain perception during the entire procedure. There was no significant difference in long term pain perception half an hour after the HSG performance.

Conclusions: This study does not support the use of EMLA for HSG.

Keywords

Hysterosalpingography Eutectic Lidocaine-Prilocaine Pain Visual Analog Scale

© 2014, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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