Iranian Journal of Radiology

Published by: Kowsar

Specific Features of Primary Central Nervous System Lymphoma in Comparison with Glioblastoma on Conventional MRI

Chao Xiang 1 , Qianxue Chen 1 , * and Yunfei Zha 2
Authors Information
1 Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China
2 Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China
Article information
  • Iranian Journal of Radiology: January 31, 2019, 16 (1); e78868
  • Published Online: November 21, 2018
  • Article Type: Research Article
  • Received: May 15, 2018
  • Revised: October 1, 2018
  • Accepted: November 12, 2018
  • DOI: 10.5812/iranjradiol78868

To Cite: Xiang C, Chen Q, Zha Y. Specific Features of Primary Central Nervous System Lymphoma in Comparison with Glioblastoma on Conventional MRI, Iran J Radiol. 2019 ; 16(1):e78868. doi: 10.5812/iranjradiol78868.

Copyright © 2018, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Haldorsen IS, Kråkenes J, Krossnes BK, Mella O, Espeland A. CT and MR imaging features of primary central nervous system lymphoma in Norway, 1989-2003. AJNR Am J Neuroradiol. 2009;30(4):744-51. doi: 10.3174/ajnr.A1447. [PubMed: 19164442].
  • 2. Haldorsen IS, Espeland A, Larsson EM. Central nervous system lymphoma: Characteristic findings on traditional and advanced imaging. AJNR Am J Neuroradiol. 2011;32(6):984-92. doi: 10.3174/ajnr.A2171. [PubMed: 20616176].
  • 3. Ponzoni M, Kwee I, Mazzucchelli L, Ferreri AJ, Zucca E, Doglioni C, et al. A virtual tissue bank for primary central nervous system lymphomas in immunocompetent individuals. Pathobiology. 2007;74(4):264-9. doi: 10.1159/000104455. [PubMed: 17709970].
  • 4. Takeuchi H, Matsuda K, Kitai R, Sato K, Kubota T. Angiogenesis in primary central nervous system lymphoma (PCNSL). J Neurooncol. 2007;84(2):141-5. doi: 10.1007/s11060-007-9363-x. [PubMed: 17406788].
  • 5. Malikova H, Koubska E, Weichet J, Klener J, Rulseh A, Liscak R, et al. Can morphological MRI differentiate between primary central nervous system lymphoma and glioblastoma? Cancer Imaging. 2016;16(1):40. doi: 10.1186/s40644-016-0098-9. [PubMed: 27894359]. [PubMed Central: PMC5126849].
  • 6. Mansour A, Qandeel M, Abdel-Razeq H, Abu Ali HA. MR imaging features of intracranial primary CNS lymphoma in immune competent patients. Cancer Imaging. 2014;14:22. doi: 10.1186/1470-7330-14-22. [PubMed: 25608570]. [PubMed Central: PMC4331827].
  • 7. Choi YS, Lee HJ, Ahn SS, Chang JH, Kang SG, Kim EH, et al. Primary central nervous system lymphoma and atypical glioblastoma: Differentiation using the initial area under the curve derived from dynamic contrast-enhanced MR and the apparent diffusion coefficient. Eur Radiol. 2017;27(4):1344-51. doi: 10.1007/s00330-016-4484-2. [PubMed: 27436023].
  • 8. Xu W, Wang Q, Shao A, Xu B, Zhang J. The performance of MR perfusion-weighted imaging for the differentiation of high-grade glioma from primary central nervous system lymphoma: A systematic review and meta-analysis. PLoS One. 2017;12(3). e0173430. doi: 10.1371/journal.pone.0173430. [PubMed: 28301491]. [PubMed Central: PMC5354292].
  • 9. da Rocha AJ, Sobreira Guedes BV, da Silveira da Rocha TM, Maia Junior AC, Chiattone CS. Modern techniques of magnetic resonance in the evaluation of primary central nervous system lymphoma: Contributions to the diagnosis and differential diagnosis. Rev Bras Hematol Hemoter. 2016;38(1):44-54. doi: 10.1016/j.bjhh.2015.12.001. [PubMed: 26969774]. [PubMed Central: PMC4786762].
  • 10. Zhang D, Hu LB, Henning TD, Ravarani EM, Zou LG, Feng XY, et al. MRI findings of primary CNS lymphoma in 26 immunocompetent patients. Korean J Radiol. 2010;11(3):269-77. doi: 10.3348/kjr.2010.11.3.269. [PubMed: 20461180]. [PubMed Central: PMC2864853].
  • 11. Coulon A, Lafitte F, Hoang-Xuan K, Martin-Duverneuil N, Mokhtari K, Blustajn J, et al. Radiographic findings in 37 cases of primary CNS lymphoma in immunocompetent patients. Eur Radiol. 2002;12(2):329-40. doi: 10.1007/s003300101037. [PubMed: 11870430].
  • 12. Masdeu JC, Quinto C, Olivera C, Tenner M, Leslie D, Visintainer P. Open-ring imaging sign: Highly specific for atypical brain demyelination. Neurology. 2000;54(7):1427-33. [PubMed: 10751251].
  • 13. Kickingereder P, Sahm F, Wiestler B, Roethke M, Heiland S, Schlemmer HP, et al. Evaluation of microvascular permeability with dynamic contrast-enhanced MRI for the differentiation of primary CNS lymphoma and glioblastoma: Radiologic-pathologic correlation. AJNR Am J Neuroradiol. 2014;35(8):1503-8. doi: 10.3174/ajnr.A3915. [PubMed: 24722313].
  • 14. Toh CH, Wei KC, Chang CN, Ng SH, Wong HF. Differentiation of primary central nervous system lymphomas and glioblastomas: Comparisons of diagnostic performance of dynamic susceptibility contrast-enhanced perfusion MR imaging without and with contrast-leakage correction. AJNR Am J Neuroradiol. 2013;34(6):1145-9. doi: 10.3174/ajnr.A3383. [PubMed: 23348763].
  • 15. Bourekas EC, Varakis K, Bruns D, Christoforidis GA, Baujan M, Slone HW, et al. Lesions of the corpus callosum: MR imaging and differential considerations in adults and children. AJR Am J Roentgenol. 2002;179(1):251-7. doi: 10.2214/ajr.179.1.1790251. [PubMed: 12076946].
  • 16. Yamashita K, Yoshiura T, Hiwatashi A, Togao O, Yoshimoto K, Suzuki SO, et al. Differentiating primary CNS lymphoma from glioblastoma multiforme: Assessment using arterial spin labeling, diffusion-weighted imaging, and (1)(8)F-fluorodeoxyglucose positron emission tomography. Neuroradiology. 2013;55(2):135-43. doi: 10.1007/s00234-012-1089-6. [PubMed: 22961074].
  • 17. Ohta K, Sano K, Suzuki T, Hidaka E, Yoshida A, Kikuchi T. B cell clonality of primary central nervous system and primary intraocular lymphomas. Jpn J Ophthalmol. 2007;51(2):147-9. doi: 10.1007/s10384-006-0406-1. [PubMed: 17401628].

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