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Test-Retest Reproducibility and Robustness Analysis of Recurrent Glioblastoma MRI Radiomics Texture Features

AUTHORS

Isaac Shiri 1 , * , Hamid Abdollahi 2 , Sajad Shaysteh 2 , Seied Rabi Mahdavi 1

1 Department of Medical Physics, Iran University of Medical science, Tehran, Iran

2 Iran University of Medical Science, Tehran, Iran

How to Cite: Shiri I, Abdollahi H, Shaysteh S, Rabi Mahdavi S. Test-Retest Reproducibility and Robustness Analysis of Recurrent Glioblastoma MRI Radiomics Texture Features, Iran J Radiol. Online ahead of Print ; 14(Special Issue):e48035. doi: 10.5812/iranjradiol.48035.

ARTICLE INFORMATION

Iranian Journal of Radiology: 14 (Special Issue); e48035
Published Online: April 12, 2017
Article Type: Abstract
Received: December 20, 2016
Accepted: February 7, 2017
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Abstract

Background: Advanced quantitative information such as radiomics features derived from magnetic resonance (MR) image may be useful for outcome prediction, prognostic models or response biomarkers in Glioblastoma (GBM), knowledge about their Reproducibility and robustness is essential. The purpose of this study was to investigate the reproducible and non-redundant radiomics texture features in oncological GBM MRI based on test-retest setup.

Methods: Thirteen patients with recurrent GBM who underwent repeated MR imaging approximately two day interval were subjected to this study. Lesions were segmented using competitive region-growing based algorithm. Following delineation and segmentation of lesions, 158 quantitative 3D features based on intensity histograms (IH), gray level run-length (GLRLM), gray level co-occurrence (GLCM), gray level size-zone texture matrices (GLSZM), neighborhood-difference matrices (NDM), and geometric features were extracted from the 3D-tumor volumes of each lesion. For every radiomics feature, test-retest was assessed with the intra-class correlation coefficient (ICC) and the concordance correlation coefficient (CCC) and finally the most reproducible and robust radiomics features were selected.

Results: Results shows that the 74% of assessed radiomics features had a high test-retest stability in terms of their ICC. There were 107 radiomics features with CCC >0.95 and 49 radiomics features were non-redundant after grouping features with R2Bet ? 0.95.

Conclusions: Test-retest and correlation analyses have identified non-redundant radiomics features and this feature are prone to errors if they employed as quantitative biomarker for GBM image analysis. However when we use robust and redundant feature, quantitative image radiomics features are informative and prognostic biomarkers for GBM Magnetic resonance imaging.

Keywords

Radiomics GBM MRI Feature

© 2017, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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