Liver Metastases of Pancreatic Cancer: Role of Repetitive Transarterial Chemoembolization (TACE) on Tumor Response and Survival

AUTHORS

Alireza Azizi 1 , * , Nagy Naghyb 1 , Parviz Farshid 1 , Emanuel M.Balisike 1 , Thomas J.Vogl 1

1 Johann Wolfgang Goethe University Hospital, Frankfurt, Germany

How to Cite: Azizi A, Naghyb N, Farshid P, M.Balisike E, J.Vogl T. Liver Metastases of Pancreatic Cancer: Role of Repetitive Transarterial Chemoembolization (TACE) on Tumor Response and Survival, Iran J Radiol. Online ahead of Print ; 11(30th Iranian Congress of Radiology):e21438. doi: 10.5812/iranjradiol.21438.

ARTICLE INFORMATION

Iranian Journal of Radiology: 11 (30th Iranian Congress of Radiology); e21438
Published Online: February 28, 2014
Article Type: Research Article
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Abstract

Background: The study was conducted to evaluate the effect of chemoembolization on pancreatic cancer liver metastases.

Patients and Methods: Thirty-two patients with pancreatic cancer liver metastases who had underwent chemoembolization (48 weeks intervals) were retrospectively enrolled into this study. Size based evaluation (RECIST) and survival indexes were assessed in general and for gender and number of lesions.

Results: 71.87% of patients showed stable disease (SD), 9.37% partial response (PR) and 18.75% progressive disease (PD). Survival rate for 1-, 3-, and 5-years from first TACE was 60%, 25%, and 11% respectively. Median survival time was 16 months and for SD group was 20 months. Progression-free survival for 6 month, 1-, 3- and 5-years was 84%, 57.3%, 20%, and 10%, respectively. There was statistically significant difference between male and female patients in their response. Survival rate for 1- and 5-years for males was 80% and 14% and for females was 47% and 0%. There was no significant difference between oligonodular liver lesion (less than 5) and multinodular (more than 5) groups. Survival rate for 1-and 5-years for oligonodular was 84% and 14% and for multinodular was 50% and 0% respectively.

Conclusions: Repetitive TACE resulted in a relevant response for the control of liver metastases of pancreatic cancer with considerable median survival time. Interestingly, this study was limited by the low number of subjects to produce significant results.

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© 2014, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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