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Imaging Features of Therapeutic Drug-Induced Disease: Part II

AUTHORS

Morteza Bajoghli 1 , * , Farshad Bajoghli 1

1 Isfahan University of Medical Sciences, Isfahan, IR Iran

How to Cite: Bajoghli M, Bajoghli F. Imaging Features of Therapeutic Drug-Induced Disease: Part II, Iran J Radiol. Online ahead of Print ; 11(30th Iranian Congress of Radiology):e21263. doi: 10.5812/iranjradiol.21263.

ARTICLE INFORMATION

Iranian Journal of Radiology: 11 (30th Iranian Congress of Radiology); e21263
Published Online: February 28, 2014
Article Type: Research Article
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Abstract

As survival rate continues to increase for patients with childhood and adult malignancies, it is important to detect disease recurrence and to find the potential complication that occurs after treatment with oncologic medication and therapeutic radiation. The most common side effect of the anthracycline drug is its cardiotoxic effect which will give the patient a decline in ejection fraction and may result in dilated cardiomyopathy. The use of isotope scan and FDG-PET exam plays an important role in diagnosis of this subclinical cardiac dysfunction. Other less common cardiotoxic side effect of chemotherapeutic medications include: arrhythmia, myocarditis, coronary artery disease, tamponade, pericarditis, and pericardial effusion. Radiation therapy can also lead to cardiotoxicity when the heart or pericardium is included in the radiation porta. Radiation-induced conditions include: pericardial disease, coronary artery disease, valvular disease, and cardiomyopathy. Many of these side effects may remain asymptomatic until late in the course of the disease and may be detected earlier. With the use of appropriate imaging modalities, radiologists should be familiar with the current knowledge and pathophysiology of these cardiac complications.

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© 2014, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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