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Detection and Severity Scoring of Chronic Obstructive Pulmonary Disease Using Volumetric Analysis of Lung CT Images

AUTHORS

Mohammad Parsa Hosseini 1 , * , Hamid Soltanian-Zadeh 3 , Shahram Akhlaghpoor 4

AUTHORS INFORMATION

1 Department of Electrical and Computer Engineering, Science and Research Branch, Islamic Azad University, mp.hosseini@ymail.com, Iran

3 Control and Intelligent Processing Center of Excellence, School of Electrical and Computer Engineering, University of Tehran, iran

4 Department of Radiology, Sina Hospital, Tehran University of Medical Sciences (TUMS), Iran

ARTICLE INFORMATION

Iranian Journal of Radiology: 9 (1); 22-7
Published Online: March 25, 2012
Article Type: Research Article
Received: January 11, 2011
Accepted: January 9, 2012
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Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a devastating disease.While there is no cure for COPD and the lung damage associated with this disease cannot be reversed, it is still very important to diagnose it as early as possible.

Objectives: In this paper, we propose a novel method based on the measurement of air trapping in the lungs from CT images to detect COPD and to evaluate its severity.

Patients and Methods: Twenty-five patients and twelve normal adults were included in this study. The proposed method found volumetric changes of the lungs from inspiration to expiration. To this end, trachea CT images at full inspiration and expiration were compared and changes in the areas and volumes of the lungs between inspiration and expiration were used to define quantitative measures (features). Using these features, the subjects were classified into two groups of normal and COPD patients using a Bayesian classifier. In addition, t-tests were applied to evaluate discrimination powers of the features for this classification.

Results: For the cases studied, the proposed method estimated air trapping in the lungs from CT images without human intervention. Based on the results, a mathematical model was developed to relate variations of lung volumes to the severity of the disease.

Conclusions: As a computer aided diagnosis (CAD) system, the proposed method may assist radiologists in the detection of COPD. It quantifies air trapping in the lungs and thus may assist them with the scoring of the disease by quantifying the severity of the disease.

Keywords

Pulmonary Disease Chronic Obstructive Diagnosis, Computer-Assisted Tomography, X-Ray Computed Lung

© 2012, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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