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Comparison of Allergic Adverse Effects and Contrast Enhancement Between Iodixanol and Iopromide

AUTHORS

Farideh Gharekhanloo 1 , * , Saadat Torabian 2

1 Department of Radiology, Besat Hospital, Hamedan University of Medical Sciences, dr_gharekhanloof@yahoo.com, Iran

2 Department of Community Medicine, Hamedan University of Medical Sciences, Iran

How to Cite: Gharekhanloo F, Torabian S. Comparison of Allergic Adverse Effects and Contrast Enhancement Between Iodixanol and Iopromide, Iran J Radiol. Online ahead of Print ; 9(2):63-66. doi: 10.5812/iranjradiol.7696.

ARTICLE INFORMATION

Iranian Journal of Radiology: 9 (2); 63-66
Published Online: June 30, 2012
Article Type: Research Article
Received: November 7, 2010
Accepted: May 20, 2012
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Abstract

Background: Iodinated X-ray contrast media are the most commonly used contrast agents in the world with an annual application of 40-50 million. New non-ionic con- trast agents are subdivided into low osmolar agents such as iopromide and iso-osmolar agents such as iodixanol. Regarding different biochemical characteristics, these agents are different in the allergic reactions and contrast enhancement and final lesion conspicuity.

Objectives: This study was carried out to compare allergic adverse effects and contrast enhancement between iodixanol and iopromide.

Patients and Methods: One-hundred and twenty patients who were referred for abdominal CT scan to Besat Hospital were included in this study. Patients were randomly divided into two groups (A and B). Group A received 100 cc iodixanol (300 mgI/mL) and group B received 100 cc iopromide (300 mgI/ml) by power injector. CT examination was performed using Helical CT Scanner (Somatom, Siemens, Germany). Sixty seconds after injection, images were obtained and enhancement of port, liver and aorta were determined. Allergic adverse effects were recorded one hour and up to one week after injection.

Results: Iodixanol produced a significantly greater enhancement of the hepatic, aorta and portal vein than iopromide (P < 0.01). Sixty seconds after injection, associated pain and heat sensation were less frequent in iodixanol in comparison with iopromide (P = 0.03). Immediate reactions such as nausea and vomiting were less frequent in iodixanol (P = 0.01). Late skin reactions such as rash was more frequent in iodixanol (P < 0.01).

Conclusions: Iodixanol is safe and is better tolerated in the early phase of injection with better contrast enhancement and lesion conspicuity. Mild late skin rash is its disadvantage.

Keywords

Iodixanol Iopromide Hypersensitivity

© 2012, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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