Decrease in Infection Rate Following Use of Povidone-Iodine During Transrectal Ultrasound Guided Biopsy of the Prostate: A Double Blind Randomized Clinical Trial

AUTHORS

Mahyar Ghafoori 2 , * , Madjid Shakiba 1 , Hamidreza Seifmanesh 1 , Kamal Hoseini 3

2 Department of Radiology, Hazrat Rasoul Akram Hospital, Tehran University of Medical Sciences, mahyarghafoori@gmail.com, Iran

1 Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences , Iran

3 Department of Urology, Hazrat Rasoul Akram Hospital, Tehran University of Medical Sciences, Iran

How to Cite: Ghafoori M, Shakiba M, Seifmanesh H, Hoseini K. Decrease in Infection Rate Following Use of Povidone-Iodine During Transrectal Ultrasound Guided Biopsy of the Prostate: A Double Blind Randomized Clinical Trial, Iran J Radiol. Online ahead of Print ; 9(2):67-70. doi: 10.5812/iranjradiol.7561.

ARTICLE INFORMATION

Iranian Journal of Radiology: 9 (2); 67-70
Published Online: June 30, 2012
Article Type: Research Article
Received: June 14, 2011
Accepted: April 21, 2012
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Abstract

Background: Infection after transrectal ultrasound (TRUS) guided biopsy of the prostate is a major and potentially life-threatening problem. Using antibiotic premedication can not completely eliminate infection after biopsy.

Objectives: We performed this study to determine the value of using povidone-iodine in prevention of post biopsy infection.

Patients and Methods: Totally, 280 patients who were referred for TRUS guided biopsy of the prostate were divided randomly into two equal groups. The case group received an intrarectal mixture of povidone-iodine and lidocaine gel before performing biopsy, while the control group received only lidocaine gel. Patients were followed up for 30 days for possible signs of infection including fever, chills and dysuria.

Results: The mean age in the case group was 68.7 7 years and 68.1 7 years in the control group (P = 0.78). Overall, there were signs and symptoms of infection in 78 patients (27.9%), of which 27 (19.3%) were in the case group, while 51 (36.4%) were in the control group (P = 0.001, OR = 2.4, 95% CI = 1.4-4.1).

Conclusion: Simple use of widely available povidone-iodine for cleaning the rectum before TRUS guided prostate biopsy can reduce the infection rate.

Keywords

Ultrasonography Biopsy Prostate Infection Povidone-Iodine

© 2012, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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