Iranian Journal of Radiology

Published by: Kowsar

Radiofrequency and Microwave Ablation in the Treatment of Hepatocellular Carcinoma

Ibrahim Halil Sever 1 , * , Metin Sucu 1 and Erhan Biyikli 1
Authors Information
1 Department of Radiology, Marmara University Medical Faculty, Istanbul, Turkey
Article information
  • Iranian Journal of Radiology: July 2018, 15 (3); e62396
  • Published Online: June 11, 2018
  • Article Type: Research Article
  • Received: October 8, 2017
  • Revised: April 17, 2018
  • Accepted: April 24, 2018
  • DOI: 10.5812/iranjradiol.62396

To Cite: Sever I H, Sucu M, Biyikli E. Radiofrequency and Microwave Ablation in the Treatment of Hepatocellular Carcinoma , Iran J Radiol. 2018 ; 15(3):e62396. doi: 10.5812/iranjradiol.62396.

Copyright © 2018, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol. 2001;2(9):533-43. doi: 10.1016/s1470-2045(01)00486-7.
  • 2. World Health Organization. Mortality Database. WHO Statistical Information System; 2008. Available from:
  • 3. Clark HP, Carson WF, Kavanagh PV, Ho CP, Shen P, Zagoria RJ. Staging and current treatment of hepatocellular carcinoma. Radiographics. 2005;25 Suppl 1:S3-23. doi: 10.1148/rg.25si055507. [PubMed: 16227495].
  • 4. Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet. 2003;362(9399):1907-17. doi: 10.1016/s0140-6736(03)14964-1.
  • 5. Llovet JM, Bruix J. Novel advancements in the management of hepatocellular carcinoma in 2008. J Hepatol. 2008;48 Suppl 1:S20-37. doi: 10.1016/j.jhep.2008.01.022. [PubMed: 18304676].
  • 6. Bruix J, Sherman M, Practice Guidelines Committee AAFTSOLD. Management of hepatocellular carcinoma. Hepatology. 2005;42(5):1208-36. doi: 10.1002/hep.20933. [PubMed: 16250051].
  • 7. Qian GJ, Wang N, Shen Q, Sheng YH, Zhao JQ, Kuang M, et al. Efficacy of microwave versus radiofrequency ablation for treatment of small hepatocellular carcinoma: experimental and clinical studies. Eur Radiol. 2012;22(9):1983-90. doi: 10.1007/s00330-012-2442-1. [PubMed: 22544225].
  • 8. Martin RC, Scoggins CR, McMasters KM. Microwave hepatic ablation: initial experience of safety and efficacy. J Surg Oncol. 2007;96(6):481-6. doi: 10.1002/jso.20750. [PubMed: 17654527].
  • 9. Shibata T, Iimuro Y, Yamamoto Y, Maetani Y, Ametani F, Itoh K, et al. Small hepatocellular carcinoma: comparison of radio-frequency ablation and percutaneous microwave coagulation therapy. Radiology. 2002;223(2):331-7. doi: 10.1148/radiol.2232010775. [PubMed: 11997534].
  • 10. Alacacioglu A, Somali I, Simsek I, Astarcioglu I, Ozkan M, Camci C, et al. Epidemiology and survival of hepatocellular carcinoma in Turkey: outcome of multicenter study. Jpn J Clin Oncol. 2008;38(10):683-8. doi: 10.1093/jjco/hyn082. [PubMed: 18753360].
  • 11. Llovet JM, Mas X, Aponte JJ, Fuster J, Navasa M, Christensen E, et al. Cost effectiveness of adjuvant therapy for hepatocellular carcinoma during the waiting list for liver transplantation. Gut. 2002;50(1):123-8. doi: 10.1136/gut.50.1.123.
  • 12. Curley SA. Radiofrequency ablation leads to excellent local tumor control and durable longterm survival in specific subsets of early stage HCC patients confirming to the Milan criteria. Ann Surg. 2010;252(6):913-4. doi: 10.1097/SLA.0b013e3182034862. [PubMed: 21107101].
  • 13. Minami Y, Kudo M. Radiofrequency ablation of hepatocellular carcinoma: Current status. World J Radiol. 2010;2(11):417-24. doi: 10.4329/wjr.v2.i11.417. [PubMed: 21179308]. [PubMed Central: PMC3006479].
  • 14. Chen MS, Li JQ, Zheng Y, Guo RP, Liang HH, Zhang YQ, et al. A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma. Ann Surg. 2006;243(3):321-8. doi: 10.1097/01.sla.0000201480.65519.b8. [PubMed: 16495695]. [PubMed Central: PMC1448947].
  • 15. Wang ZL, Liang P, Dong BW, Yu XL, Yu DJ. Prognostic Factors and Recurrence of Small Hepatocellular Carcinoma after Hepatic Resection or Microwave Ablation: A Retrospective Study. J Gastrointest Surg. 2007;12(2):327-37. doi: 10.1007/s11605-007-0310-0.
  • 16. Guglielmi A, Ruzzenente A, Valdegamberi A, Pachera S, Campagnaro T, D'Onofrio M, et al. Radiofrequency ablation versus surgical resection for the treatment of hepatocellular carcinoma in cirrhosis. J Gastrointest Surg. 2008;12(1):192-8. doi: 10.1007/s11605-007-0392-8. [PubMed: 17999123].
  • 17. Hiraoka A, Horiike N, Yamashita Y, Koizumi Y, Doi K, Yamamoto Y, et al. Efficacy of radiofrequency ablation therapy compared to surgical resection in 164 patients in Japan with single hepatocellular carcinoma smaller than 3 cm, along with report of complications. Hepatogastroenterology. 2008;55(88):2171-4. [PubMed: 19260499].
  • 18. Guo WX, Sun JX, Cheng YQ, Shi J, Li N, Xue J, et al. Percutaneous radiofrequency ablation versus partial hepatectomy for small centrally located hepatocellular carcinoma. World J Surg. 2013;37(3):602-7. doi: 10.1007/s00268-012-1870-z. [PubMed: 23212793].
  • 19. Huang J, Yan L, Cheng Z, Wu H, Du L, Wang J, et al. A randomized trial comparing radiofrequency ablation and surgical resection for HCC conforming to the Milan criteria. Ann Surg. 2010;252(6):903-12. doi: 10.1097/SLA.0b013e3181efc656. [PubMed: 21107100].
  • 20. Zhang Z, Zhang L, Wang N, Shen Q, Cheng W, Qian G. Therapeutic Efficacy of Percutaneous Radiofrequency Ablation versus Microwave Ablation for Hepatocellular Carcinoma. PLoS ONE. 2013;8(10). e76119. doi: 10.1371/journal.pone.0076119.
  • 21. Lu MD, Chen JW, Xie XY, Liu L, Huang XQ, Liang LJ, et al. Hepatocellular carcinoma: US-guided percutaneous microwave coagulation therapy. Radiology. 2001;221(1):167-72. doi: 10.1148/radiol.2211001783. [PubMed: 11568335].
  • 22. Dong B, Liang P, Yu X, Su L, Yu D, Cheng Z, et al. Percutaneous sonographically guided microwave coagulation therapy for hepatocellular carcinoma: results in 234 patients. AJR Am J Roentgenol. 2003;180(6):1547-55. doi: 10.2214/ajr.180.6.1801547. [PubMed: 12760916].
  • 23. Beppu T, Ogawa M, Matsuda T, Ohara C, Hirota M, Shimada S, et al. [Efficacy of microwave coagulation therapy (MCT) in patients with liver tumors]. Gan To Kagaku Ryoho. 1998;25(9):1358-61. [PubMed: 9703828].
  • 24. Buscarini L, Buscarini E, Di Stasi M, Vallisa D, Quaretti P, Rocca A. Percutaneous radiofrequency ablation of small hepatocellular carcinoma: long-term results. Eur Radiol. 2001;11(6):914-21. doi: 10.1007/s003300000659. [PubMed: 11419162].
  • 25. Poon RT, Fan ST, Tsang FH, Wong J. Locoregional therapies for hepatocellular carcinoma: a critical review from the surgeon's perspective. Ann Surg. 2002;235(4):466-86. [PubMed: 11923602]. [PubMed Central: PMC1422461].
  • 26. Xu HX, Xie XY, Lu MD, Chen JW, Yin XY, Xu ZF, et al. Ultrasound-guided percutaneous thermal ablation of hepatocellular carcinoma using microwave and radiofrequency ablation. Clin Radiol. 2004;59(1):53-61. [PubMed: 14697375].

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