Iranian Journal of Radiology

Published by: Kowsar

Prediction of Renal Cortical Involvement Using Serum and Urinary Inflammatory Markers in Children with Febrile Urinary Tract Infection

Mitra Naseri 1 , * , Malihe Banihasan 1 and Seyed Ali Alamdaran 2
Authors Information
1 Department of Nephrology, Dr. Sheikh Children Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Radiology, Dr. Sheikh Children Hospital, Mashhad University of Medical sciences, Mashhad, Iran
Article information
  • Iranian Journal of Radiology: April 2017, 14 (2); e41485
  • Published Online: February 20, 2017
  • Article Type: Research Article
  • Received: August 20, 2016
  • Revised: December 5, 2016
  • Accepted: January 4, 2017
  • DOI: 10.5812/iranjradiol.41485

To Cite: Naseri M, Banihasan M, Alamdaran S A. Prediction of Renal Cortical Involvement Using Serum and Urinary Inflammatory Markers in Children with Febrile Urinary Tract Infection, Iran J Radiol. 2017 ; 14(2):e41485. doi: 10.5812/iranjradiol.41485.

Copyright © 2017, Tehran University of Medical Sciences and Iranian Society of Radiology. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Study Objective and Hypothesis
3. Patients and Methods
4. Results
5. Discussion
  • 1. Jung SJ, Lee JH. Prediction of Cortical Defect Using C-Reactive Protein and Urine Sodium to Potassium Ratio in Infants with Febrile Urinary Tract Infection. Yonsei Med J. 2016; 57(1): 103-10[DOI][PubMed]
  • 2. Busch R, Huland H. Correlation of symptoms and results of direct bacterial localization in patients with urinary tract infections. J Urol. 1984; 132(2): 282-5[PubMed]
  • 3. Printza N, Farmaki E, Piretzi K, Arsos G, Kollios K, Papachristou F. Acute phase 99mTc-dimercaptosuccinic acid scan in infants with first episode of febrile urinary tract infection. World J Pediatr. 2012; 8(1): 52-6[DOI][PubMed]
  • 4. Majd M, Rushton HG. Renal cortical scintigraphy in the diagnosis of acute pyelonephritis. Semin Nucl Med. 1992; 22(2): 98-111[PubMed]
  • 5. Handmaker H. Nuclear renal imaging in acute pyelonephritis. Semin Nucl Med. 1982; 12(3): 246-53[PubMed]
  • 6. Traisman ES, Conway JJ, Traisman HS, Yogev R, Firlit C, Shkolnik A, et al. The localization of urinary tract infection with 99mTc glucoheptonate scintigraphy. Pediatr Radiol. 1986; 16(5): 403-6[PubMed]
  • 7. Sty JR, Wells RG, Starshak RJ, Schroeder BA. Imaging in acute renal infection in children. AJR Am J Roentgenol. 1987; 148(3): 471-7[DOI][PubMed]
  • 8. Bjorgvinsson E, Majd M, Eggli KD. Diagnosis of acute pyelonephritis in children: comparison of sonography and 99mTc-DMSA scintigraphy. AJR Am J Roentgenol. 1991; 157(3): 539-43[DOI][PubMed]
  • 9. Winberg J, Bollgren I, Kallenius G, Mollby R, Svenson SB. Clinical pyelonephritis and focal renal scarring. A selected review of pathogenesis, prevention, and prognosis. Pediatr Clin North Am. 1982; 29(4): 801-14[PubMed]
  • 10. Ransley PG, Risdon RA. Reflux nephropathy: effects of antimicrobial therapy on the evolution of the early pyelonephritic scar. Kidney Int. 1981; 20(6): 733-42[PubMed]
  • 11. Glauser MP, Lyons JM, Braude AI. Prevention of chronic experimental pyelonephritis by suppression of acute suppuration. J Clin Invest. 1978; 61(2): 403-7[DOI][PubMed]
  • 12. Ayazi P, Mahyar A, Daneshi MM, Jahani Hashemi H, Pirouzi M, Esmailzadehha N. Diagnostic Accuracy of the Quantitative C-Reactive Protein, Erythrocyte Sedimentation Rate and White Blood Cell Count in Urinary Tract Infections among Infants and Children. Malays J Med Sci. 2013; 20(5): 40-6[PubMed]
  • 13. Gurgoze MK, Akarsu S, Yilmaz E, Godekmerdan A, Akca Z, Ciftci I, et al. Proinflammatory cytokines and procalcitonin in children with acute pyelonephritis. Pediatr Nephrol. 2005; 20(10): 1445-8[DOI][PubMed]
  • 14. Naseri M. Alterations of peripheral leukocyte count, erythrocyte sedimentation rate, and C-reactive protein in febrile urinary tract infection. Iran J Kidney Dis. 2008; 2(3): 137-42[PubMed]
  • 15. Kaye D, Rocha H. Urinary concentrating ability in early experimental pyelonephritis. J Clin Invest. 1970; 49(7): 1427-37[DOI][PubMed]
  • 16. Martinez-Maldonado M, Opava-Stitzer S. Pathophysiology of the Kidney. 1977; : 992-1028
  • 17. Berg U. Renal function in acute febrile urinary tract infection in children: pathophysiologic aspects on the reduced concentrating capacity. Kidney Int. 1981; 20(6): 753-8[PubMed]
  • 18. Kass EJ, Fink-Bennett D, Cacciarelli AA, Balon H, Pavlock S. The sensitivity of renal scintigraphy and sonography in detecting nonobstructive acute pyelonephritis. J Urol. 1992; 148(2 Pt 2): 606-8[PubMed]
  • 19. A radiopharmaceuticals schedule for imaging pediatrics. Eur J Nucl Med. 1990; 2: 98-111
  • 20. Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig L, et al. STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies. BMJ. 2015; 351[DOI][PubMed]
  • 21. Nicavar A, Sharifian M, Mohkam M. Assessment of fever ,WBC,ESR and CRP in first urinary tract infection. J Qazvin Univ Med sci. 2004; 31: 41-4
  • 22. Choi DM, Heo TH, Yim HE, Yoo KH. Evaluation of new American Academy of Pediatrics guideline for febrile urinary tract infection. Korean J Pediatr. 2015; 58(9): 341-6[DOI][PubMed]
  • 23. Mohkam M, Maham S, Rahmani A, Naghi I, Otokesh B, Raiiati H, et al. Technetium Tc 99m dimercaptosuccinic acid renal scintigraphy in children with acute pyelonephritis: correlation with other imaging tests. Iran J Kidney Dis. 2010; 4(4): 297-301[PubMed]
  • 24. Hoberman A, Charron M, Hickey RW, Baskin M, Kearney DH, Wald ER. Imaging studies after a first febrile urinary tract infection in young children. N Engl J Med. 2003; 348(3): 195-202[DOI][PubMed]
  • 25. Riccabona M, Avni FE, Blickman JG, Dacher JN, Darge K, Lobo ML, et al. Imaging recommendations in paediatric uroradiology: minutes of the ESPR workgroup session on urinary tract infection, fetal hydronephrosis, urinary tract ultrasonography and voiding cystourethrography, Barcelona, Spain, June 2007. Pediatr Radiol. 2008; 38(2): 138-45[DOI][PubMed]
  • 26. Lim R. Vesicoureteral reflux and urinary tract infection: evolving practices and current controversies in pediatric imaging. AJR Am J Roentgenol. 2009; 192(5): 1197-208[DOI][PubMed]
  • 27. Jack SE. Nelson textbook of pediatrics. 2011; : 1829-34
  • 28. Pecile P, Miorin E, Romanello C, Falleti E, Valent F, Giacomuzzi F, et al. Procalcitonin: a marker of severity of acute pyelonephritis among children. Pediatrics. 2004; 114(2)-54[PubMed]
  • 29. Jung JI, Lim DH, Yim HE, Park MS, Yoo KH, Hong YS, et al. Fever Duration and Renal Scar in Pediatric Urinary Tract Infection. J Korean Soc Pediatr Nephrol. 2008; 12(1): 70[DOI]
  • 30. Levtchenko EN, Lahy C, Levy J, Ham HR, Piepsz A. Role of Tc-99m DMSA scintigraphy in the diagnosis of culture negative pyelonephritis. Pediatr Nephrol. 2001; 16(6): 503-6[PubMed]
  • 31. Majd M, Rushton HG, Jantausch B, Wiedermann BL. Relationship among vesicoureteral reflux, P-fimbriated Escherichia coli, and acute pyelonephritis in children with febrile urinary tract infection. J Pediatr. 1991; 119(4): 578-85[PubMed]
  • 32. Ansari Gilani K, Modaresi Esfeh J, Gholamrezanezhad A, Gholami A, Mamishi S, Eftekhari M, et al. Predictors of abnormal renal cortical scintigraphy in children with first urinary tract infection: the importance of time factor. Int Urol Nephrol. 2010; 42(4): 1041-7[DOI][PubMed]
  • 33. Biggi A, Dardanelli L, Pomero G, Cussino P, Noello C, Sernia O, et al. Acute renal cortical scintigraphy in children with a first urinary tract infection. Pediatr Nephrol. 2001; 16(9): 733-8[DOI][PubMed]
  • 34. Nammalwar BR, Vijayakumar M, Sankar J, Ramnath B, Prahlad N. Evaluation of the use of DMSA in culture positive UTI and culture negative acute pyelonephritis. Indian Pediatr. 2005; 42(7): 691-6[PubMed]
  • 35. Ataei N, Madani A, Habibi R, Khorasani M. Evaluation of acute pyelonephritis with DMSA scans in children presenting after the age of 5 years. Pediatr Nephrol. 2005; 20(10): 1439-44[DOI][PubMed]
  • 36. Mandell GA, Eggli DF, Gilday DL, Heyman S, Leonard JC, Miller JH. Society of nuclear medicine procedure guidelines manual. 2003; : 195-8
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