Iranian Journal of Radiology

Published by: Shiraz University of Medical Sciences

Agreement Between High-Resolution Computed Tomography and Pathological Tumor Size of Lung Adenocarcinoma: Influence of Ground Glass Opacity Ratio

Hongliang Sun 1 , * , Yanyan Xu 1 , Zhenrong Zhang 2 and Wu Wang 1
Authors Information
1 Department of Radiology, China-Japan Friendship Hospital, Beijing, China
2 Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing, China
Article information
  • Iranian Journal of Radiology: October 2017, 14 (4); e22027
  • Published Online: October 7, 2017
  • Article Type: Research Article
  • Received: January 13, 2017
  • Revised: February 11, 2017
  • Accepted: March 18, 2017
  • DOI: 10.5812/iranjradiol.22027

To Cite: Sun H, Xu Y, Zhang Z, Wang W. Agreement Between High-Resolution Computed Tomography and Pathological Tumor Size of Lung Adenocarcinoma: Influence of Ground Glass Opacity Ratio, Iran J Radiol. 2017 ;14(4):e22027. doi: 10.5812/iranjradiol.22027.

Copyright: Copyright © 2017, Iranian Journal of Radiology. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Henschke CI, Yankelevitz DF, Mirtcheva R, McGuinness G, McCauley D, Miettinen OS, et al. CT screening for lung cancer: frequency and significance of part-solid and nonsolid nodules. AJR Am J Roentgenol. 2002;178(5):1053-7. doi: 10.2214/ajr.178.5.1781053. [PubMed: 11959700].
  • 2. Kim HY, Shim YM, Lee KS, Han J, Yi CA, Kim YK. Persistent pulmonary nodular ground-glass opacity at thin-section CT: histopathologic comparisons. Radiology. 2007;245(1):267-75. doi: 10.1148/radiol.2451061682. [PubMed: 17885195].
  • 3. Nakata M, Sawada S, Yamashita M, Saeki H, Kurita A, Takashima S, et al. Objective radiologic analysis of ground-glass opacity aimed at curative limited resection for small peripheral non-small cell lung cancer. J Thorac Cardiovasc Surg. 2005;129(6):1226-31. doi: 10.1016/j.jtcvs.2004.10.032. [PubMed: 15942561].
  • 4. Lee HJ, Kim YT, Kang CH, Zhao B, Tan Y, Schwartz LH, et al. Epidermal growth factor receptor mutation in lung adenocarcinomas: relationship with CT characteristics and histologic subtypes. Radiology. 2013;268(1):254-64. doi: 10.1148/radiol.13112553. [PubMed: 23468578].
  • 5. Murakawa T, Konoeda C, Ito T, Inoue Y, Sano A, Nagayama K, et al. The ground glass opacity component can be eliminated from the T-factor assessment of lung adenocarcinoma. Eur J Cardiothorac Surg. 2013;43(5):925-32. doi: 10.1093/ejcts/ezs467. [PubMed: 23047267].
  • 6. Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, et al. International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol. 2011;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. [PubMed: 21252716].
  • 7. Naidich DP, Bankier AA, MacMahon H, Schaefer-Prokop CM, Pistolesi M, Goo JM, et al. Recommendations for the management of subsolid pulmonary nodules detected at CT: a statement from the Fleischner Society. Radiology. 2013;266(1):304-17. doi: 10.1148/radiol.12120628. [PubMed: 23070270].
  • 8. Botea F, Marconi M, Lutman F, Balzarini L, Roncalli M, Montorsi M, et al. Radiological estimation of size in colorectal liver metastases: is it reliable? Comparison with post-resectional measurements. Updates Surg. 2010;62(1):21-6. doi: 10.1007/s13304-010-0004-0. [PubMed: 20845097].
  • 9. Torkzad M, Lindholm J, Martling A, Blomqvist L. Retrospective measurement of different size parameters of non-radiated rectal cancer on MR images and pathology slides and their comparison. Eur Radiol. 2003;13(10):2271-7. doi: 10.1007/s00330-003-1898-4. [PubMed: 12740710].
  • 10. Innocenti P, Fiumicelli D, Agostini S, Savino L, Taddei G, Santoni R, et al. Magnetic resonance imaging in the measurement of clinical stage IB cervical carcinoma. Eur J Radiol. 1996;23(3):222-7. doi: 10.1016/S0720-048X(96)00773-5. [PubMed: 9003929].
  • 11. Ridge CA, Huang J, Cardoza S, Zabor EC, Moskowitz CS, Zakowski MF, et al. Comparison of multiplanar reformatted CT lung tumor measurements to axial tumor measurement alone: impact on maximal tumor dimension and T stage. AJR Am J Roentgenol. 2013;201(5):959-63. doi: 10.2214/AJR.12.10033. [PubMed: 24147464].
  • 12. Lampen-Sachar K, Zhao B, Zheng J, Moskowitz CS, Schwartz LH, Zakowski MF, et al. Correlation between tumor measurement on Computed Tomography and resected specimen size in lung adenocarcinomas. Lung Cancer. 2012;75(3):332-5. doi: 10.1016/j.lungcan.2011.08.001. [PubMed: 21890229].
  • 13. Lee KH, Goo JM, Park SJ, Wi JY, Chung DH, Go H, et al. Correlation between the size of the solid component on thin-section CT and the invasive component on pathology in small lung adenocarcinomas manifesting as ground-glass nodules. J Thorac Oncol. 2014;9(1):74-82. doi: 10.1097/JTO.0000000000000019. [PubMed: 24346095].
  • 14. Isaka T, Yokose T, Ito H, Imamura N, Watanabe M, Imai K, et al. Comparison between CT tumor size and pathological tumor size in frozen section examinations of lung adenocarcinoma. Lung Cancer. 2014;85(1):40-6. doi: 10.1016/j.lungcan.2014.03.023. [PubMed: 24751107].
  • 15. Vazquez M, Carter D, Brambilla E, Gazdar A, Noguchi M, Travis WD, et al. Solitary and multiple resected adenocarcinomas after CT screening for lung cancer: histopathologic features and their prognostic implications. Lung Cancer. 2009;64(2):148-54. doi: 10.1016/j.lungcan.2008.08.009. [PubMed: 18951650].
  • 16. Suzuki K, Kusumoto M, Watanabe S, Tsuchiya R, Asamura H. Radiologic classification of small adenocarcinoma of the lung: radiologic-pathologic correlation and its prognostic impact. Ann Thorac Surg. 2006;81(2):413-9. doi: 10.1016/j.athoracsur.2005.07.058. [PubMed: 16427823].
  • 17. Matsuguma H, Oki I, Nakahara R, Suzuki H, Kasai T, Kamiyama Y, et al. Comparison of three measurements on computed tomography for the prediction of less invasiveness in patients with clinical stage I non-small cell lung cancer. Ann Thorac Surg. 2013;95(6):1878-84. doi: 10.1016/j.athoracsur.2013.02.022. [PubMed: 23618519].
  • 18. Tateishi U, Uno H, Yonemori K, Satake M, Takeuchi M, Arai Y. Prediction of lung adenocarcinoma without vessel invasion: a CT scan volumetric analysis. Chest. 2005;128(5):3276-83. doi: 10.1378/chest.128.5.3276. [PubMed: 16304272].
  • 19. Oda S, Awai K, Murao K, Ozawa A, Utsunomiya D, Yanaga Y, et al. Volume-doubling time of pulmonary nodules with ground glass opacity at multidetector CT: Assessment with computer-aided three-dimensional volumetry. Acad Radiol. 2011;18(1):63-9. doi: 10.1016/j.acra.2010.08.022. [PubMed: 21145028].
  • 20. Sumikawa H, Johkoh T, Nagareda T, Sekiguchi J, Matsuo K, Fujita Y, et al. Pulmonary adenocarcinomas with ground-glass attenuation on thin-section CT: quantification by three-dimensional image analyzing method. Eur J Radiol. 2008;65(1):104-11. doi: 10.1016/j.ejrad.2007.03.013. [PubMed: 17466475].
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