Iranian Journal of Radiology

Published by: Kowsar

Changes of T2 Relaxation Time From Neoadjuvant Chemotherapy in Breast Cancer Lesions

Li Liu 1 , Bo Yin 2 , Dao Ying Geng 2 , Yi Ping Lu 2 and Wei Jun Peng 1 , *
Authors Information
1 Department of Radiology, Shanghai Cancer Center, Fudan University, Shanghai, China
2 Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China
Article information
  • Iranian Journal of Radiology: July 01, 2016, 13 (3); e24014
  • Published Online: January 9, 2016
  • Article Type: Research Article
  • Received: September 28, 2014
  • Revised: May 20, 2015
  • Accepted: June 16, 2015
  • DOI: 10.5812/iranjradiol.24014

To Cite: Liu L, Yin B, Geng D Y, Lu Y P, Peng W J. Changes of T2 Relaxation Time From Neoadjuvant Chemotherapy in Breast Cancer Lesions, Iran J Radiol. 2016 ; 13(3):e24014. doi: 10.5812/iranjradiol.24014.

Copyright © 2016, Tehran University of Medical Sciences and Iranian Society of Radiology. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. von Minckwitz G, Costa SD, Eiermann W, Blohmer JU, Tulusan AH, Jackisch C, et al. Maximized reduction of primary breast tumor size using preoperative chemotherapy with doxorubicin and docetaxel. J clinic oncol. 1999; 17(7)
  • 2. Omranipour R, Alipour S, Hadji M, Fereidooni F, Jahanzad I, Bagheri K. Accuracy of estrogen and progesterone receptor assessment in core needle biopsy specimens of breast cancer. Iran Red Crescent Med J. 2013; 15(6): 515-8[DOI][PubMed]
  • 3. Bahreini L, Fatemizadeh E, Guity M. Diagnostic efficacy of all series of dynamic contrast enhanced breast MR images using gradient vector flow (GVF) segmentation and novel border feature extraction for differentiation between malignant and benign breast lesions. Iran J Radiol. 2010; 7(4): 225-34
  • 4. Bluemke DA, Gatsonis CA, Chen MH, DeAngelis GA, DeBruhl N, Harms S, et al. Magnetic resonance imaging of the breast prior to biopsy. JAMA. 2004; 292(22): 2735-42[DOI][PubMed]
  • 5. Ahmadinejad N, Movahedinia S, Movahedinia S, Shahriari M. Association of mammographic density with pathologic findings. Iran Red Crescent Med J. 2013; 15(12)[DOI][PubMed]
  • 6. Nadrljanski MM, Markovic BB, Milosevic ZC. Breast ductal carcinoma in situ: morphologic and kinetic MRI findings. Iran J Radiol. 2013; 10(2): 99-102[DOI][PubMed]
  • 7. Bahri S, Chen JH, Mehta RS, Carpenter PM, Nie K, Kwon SY, et al. Residual breast cancer diagnosed by MRI in patients receiving neoadjuvant chemotherapy with and without bevacizumab. Ann Surg Oncol. 2009; 16(6): 1619-28[DOI][PubMed]
  • 8. Kriege M, Brekelmans CT, Boetes C, Besnard PE, Zonderland HM, Obdeijn IM, et al. Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. N Engl J Med. 2004; 351(5): 427-37[DOI][PubMed]
  • 9. Carneiro AAO, Vilela GR, de Araujo DB, Baffa O. MRI relaxometry: methods appl. Braz J Phys. 2006; 36: 9-15
  • 10. Tan PC, Pickles MD, Lowry M, Manton DJ, Turnbull LW. Lesion T(2) relaxation times and volumes predict the response of malignant breast lesions to neoadjuvant chemotherapy. Magn Reson Imaging. 2008; 26(1): 26-34[DOI][PubMed]
  • 11. Merchant TE, Thelissen GR, de Graaf PW, Nieuwenhuizen CW, Kievit HC, Den Otter W. Application of a mixed imaging sequence for MR imaging characterization of human breast disease. Acta Radiol. 1993; 34(4): 356-61[PubMed]
  • 12. Edden RA, Smith SA, Barker PB. Longitudinal and multi-echo transverse relaxation times of normal breast tissue at 3 Tesla. J Magn Reson Imaging. 2010; 32(4): 982-7[DOI][PubMed]
  • 13. Kurosumi M, Akiyama F, Iwase T, Motomura K, Okazaki M, Tsuda H, et al. Histopathological criteria for assessment of therapeutic response in breast cancer. Breast Cancer. 2001; 8(1): 1-2[PubMed]
  • 14. Williamson DS, Mulken RV, Jakab PD, Jolesz FA. Coherence transfer by isotropic mixing in Carr-Purcell-Meiboom-Gill imaging: implications for the bright fat phenomenon in fast spin-echo imaging. Magn Reson Med. 1996; 35(4): 506-13[PubMed]
  • 15. Chaland B, Mariette F, Marchal P, De Certaines J. 1H nuclear magnetic resonance relaxometric characterization of fat and water states in soft and hard cheese. J Dairy Res. 2000; 67(4): 609-18[PubMed]
  • 16. Gossuin Y, Roch A, Muller RN, Gillis P. Relaxation induced by ferritin and ferritin-like magnetic particles: The role of proton exchange. Mag Reson Medic. 2000; 43(2): 237-43[DOI]
  • 17. Braunschweiger PG. Effect of cyclophosphamide on the pathophysiology of RIF-1 solid tumors. Cancer Res. 1988; 48(15): 4206-10[PubMed]
  • 18. Duvvuri U, Poptani H, Feldman M, Nadal-Desbarats L, Gee MS, Lee WM, et al. Quantitative T1rho magnetic resonance imaging of RIF-1 tumors in vivo: detection of early response to cyclophosphamide therapy. Cancer Res. 2001; 61(21): 7747-53[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments