Iranian Journal of Radiology

Published by: Kowsar

Diffusion Weighted Imaging in Acute Attacks of Multiple Sclerosis

Yasmin Davoudi 1 , Mohsen Foroughipour 2 , Reza Torabi 3 , Parvaneh Layegh 1 , Nassim Matin 4 and Ali Shoeibi 2 , *
Authors Information
1 Department of Radiology, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Neurology, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3 Department of Radiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4 School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Article information
  • Iranian Journal of Radiology: April 01, 2016, 13 (2); e21740
  • Published Online: February 15, 2016
  • Article Type: Research Article
  • Received: July 5, 2014
  • Revised: October 4, 2014
  • Accepted: October 7, 2014
  • DOI: 10.5812/iranjradiol.21740

To Cite: Davoudi Y, Foroughipour M, Torabi R, Layegh P, Matin N, et al. Diffusion Weighted Imaging in Acute Attacks of Multiple Sclerosis, Iran J Radiol. 2016 ; 13(2):e21740. doi: 10.5812/iranjradiol.21740.

Copyright © 2016, Tehran University of Medical Sciences and Iranian Society of Radiology. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Hygino da Cruz LJ, Batista RR, Domingues RC, Barkhof F. Diffusion magnetic resonance imaging in multiple sclerosis. Neuroimaging Clin N Am. 2011; 21(1): 71-88[DOI][PubMed]
  • 2. Izadi S, Nikseresht A, Sharifian M, Sahraian MA, Hamidian Jahromi A, Aghighi M, et al. Significant increase in the prevalence of multiple sclerosis in iran in 2011. Iran J Med Sci. 2014; 39(2): 152-3[PubMed]
  • 3. Dutta R, Trapp BD. Relapsing and progressive forms of multiple sclerosis: insights from pathology. Curr Opin Neurol. 2014; 27(3): 271-8[DOI][PubMed]
  • 4. Traboulsee AL, Li DK. The role of MRI in the diagnosis of multiple sclerosis. Adv Neurol. 2006; 98: 125-46[PubMed]
  • 5. Rahimian N, Saligheh Rad H, Firouznia K, Ebrahimzadeh SA, Meysamie A, Vafaiean H, et al. Magnetic resonance spectroscopic findings of chronic lesions in two subtypes of multiple sclerosis: primary progressive versus relapsing remitting. Iran J Radiol. 2013; 10(3): 128-32[DOI][PubMed]
  • 6. Simon JH, Bermel RA, Rudick RA. Simple MRI metrics contribute to optimal care of the patient with multiple sclerosis. AJNR Am J Neuroradiol. 2014; 35(5): 831-2[DOI][PubMed]
  • 7. Alizadeh A, Roudbari SA, Heidarzadeh A, Kouhsari M. Comparison between immediate and delayed imaging after gadolinium chelate injection for detecting enhanced lesions in multiple sclerosis. Iran J Radiol. 2010; 7(4): 235-9
  • 8. Phuttharak W, Galassi W, Laopaiboon V, Laopaiboon M, Hesselink JR. Abnormal diffusivity of normal appearing brain tissue in multiple sclerosis: a diffusion-weighted MR imaging study. J Med Assoc Thai. 2007; 90(12): 2689-94[PubMed]
  • 9. Yurtsever I, Hakyemez B, Taskapilioglu O, Erdogan C, Turan OF, Parlak M. The contribution of diffusion-weighted MR imaging in multiple sclerosis during acute attack. Eur J Radiol. 2008; 65(3): 421-6[DOI][PubMed]
  • 10. Larsson HB, Thomsen C, Frederiksen J, Stubgaard M, Henriksen O. In vivo magnetic resonance diffusion measurement in the brain of patients with multiple sclerosis. Magn Reson Imaging. 1992; 10(1): 7-12[PubMed]
  • 11. Castriota-Scanderbeg A, Sabatini U, Fasano F, Floris R, Fraracci L, Mario MD, et al. Diffusion of water in large demyelinating lesions: a follow-up study. Neuroradiology. 2002; 44(9): 764-7[DOI][PubMed]
  • 12. Rueda-Lopes FC, Hygino da Cruz LJ, Doring TM, Gasparetto EL. Diffusion-weighted imaging and demyelinating diseases: new aspects of an old advanced sequence. AJR Am J Roentgenol. 2014; 202(1)-42[DOI][PubMed]
  • 13. Lo CP, Kao HW, Chen SY, Chu CM, Hsu CC, Chen YC, et al. Comparison of diffusion-weighted imaging and contrast-enhanced T1-weighted imaging on a single baseline MRI for demonstrating dissemination in time in multiple sclerosis. BMC Neurol. 2014; 14: 100[DOI][PubMed]
  • 14. Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011; 69(2): 292-302[DOI][PubMed]
  • 15. Jelescu IO, Leppert IR, Narayanan S, Araujo D, Arnold DL, Pike GB. Dual-temporal resolution dynamic contrast-enhanced MRI protocol for blood-brain barrier permeability measurement in enhancing multiple sclerosis lesions. J Magn Reson Imaging. 2011; 33(6): 1291-300[DOI][PubMed]
  • 16. Huisman TA, Sorensen AG, Hergan K, Gonzalez RG, Schaefer PW. Diffusion-weighted imaging for the evaluation of diffuse axonal injury in closed head injury. J Comput Assist Tomogr. 2003; 27(1): 5-11[PubMed]
  • 17. Rosso C, Remy P, Creange A, Brugieres P, Cesaro P, Hosseini H. Diffusion-weighted MR imaging characteristics of an acute strokelike form of multiple sclerosis. AJNR Am J Neuroradiol. 2006; 27(5): 1006-8[PubMed]
  • 18. Bugnicourt JM, Garcia PY, Monet P, Bonnaire B, Al Khedr A, Godefroy O. Teaching NeuroImages: marked reduced apparent diffusion coefficient in acute multiple sclerosis lesion. Neurology. 2010; 74(20)[DOI][PubMed]
  • 19. Eisele P, Szabo K, Griebe M, Rossmanith C, Forster A, Hennerici M, et al. Reduced diffusion in a subset of acute MS lesions: a serial multiparametric MRI study. AJNR Am J Neuroradiol. 2012; 33(7): 1369-73[DOI][PubMed]
  • 20. Pagani E, Bammer R, Horsfield MA, Rovaris M, Gass A, Ciccarelli O, et al. Diffusion MR imaging in multiple sclerosis: technical aspects and challenges. AJNR Am J Neuroradiol. 2007; 28(3): 411-20[PubMed]
  • 21. Iwasawa T, Matoba H, Ogi A, Kurihara H, Saito K, Yoshida T, et al. Diffusion-weighted imaging of the human optic nerve: a new approach to evaluate optic neuritis in multiple sclerosis. Magn Reson Med. 1997; 38(3): 484-91[PubMed]
  • 22. Bhatia R, Garg A. Diffusion abnormality detects an acute demyelinating lesion due to probable multiple sclerosis. Indian J Radiol Imaging. 2007; 17(1): 20
  • 23. Balasubramanya KS, Kovoor JM, Jayakumar PN, Ravishankar S, Kamble RB, Panicker J, et al. Diffusion-weighted imaging and proton MR spectroscopy in the characterization of acute disseminated encephalomyelitis. Neuroradiology. 2007; 49(2): 177-83[DOI][PubMed]
  • 24. Balashov KE, Aung LL, Dhib-Jalbut S, Keller IA. Acute multiple sclerosis lesion: conversion of restricted diffusion due to vasogenic edema. J Neuroimaging. 2011; 21(2): 202-4[DOI][PubMed]
  • 25. Balashov KE, Lindzen E. Acute demyelinating lesions with restricted diffusion in multiple sclerosis. Mult Scler. 2012; 18(12): 1745-53[DOI][PubMed]
  • 26. Saharian M, Shakaouri Rad A, Motamedi M, Pakdaman H, Radue E. Magnetic resonance imaging abnormalities in multiple sclerosis: A review. Iran J Radiol. 2007; 4(4): 231-9
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