Iranian Journal of Radiology

Published by: Kowsar

Effects of Variations of Flow and Heart Rate on Intra-Aneurysmal Hemodynamics in a Ruptured Internal Carotid Artery Aneurysm During Exercise

Ali Sarrami-Foroushani 1 , Mohsen Nasr Esfahany 1 , * , Hamidreza Saligheh Rad 2 , Kavous Firouznia 3 , Madjid Shakiba 3 and Hossein Ghanaati 3
Authors Information
1 Department of Chemical Engineering, Isfahan University of Technology, Isfahan, Iran
2 Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran
3 Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran
Article information
  • Iranian Journal of Radiology: January 01, 2016, 13 (1); e18217
  • Published Online: January 2, 2016
  • Article Type: Research Article
  • Received: February 13, 2014
  • Revised: June 18, 2014
  • Accepted: July 20, 2014
  • DOI: 10.5812/iranjradiol.18217

To Cite: Sarrami-Foroushani A, Nasr Esfahany M, Saligheh Rad H, Firouznia K, Shakiba M, et al. Effects of Variations of Flow and Heart Rate on Intra-Aneurysmal Hemodynamics in a Ruptured Internal Carotid Artery Aneurysm During Exercise, Iran J Radiol. 2016 ; 13(1):e18217. doi: 10.5812/iranjradiol.18217.

Copyright © 2016, Tehran University of Medical Sciences and Iranian Society of Radiology. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Meng H, Tutino VM, Xiang J, Siddiqui A. High WSS or low WSS? Complex interactions of hemodynamics with intracranial aneurysm initiation, growth, and rupture: toward a unifying hypothesis. AJNR Am J Neuroradiol. 2014; 35(7): 1254-62[DOI]
  • 2. Meng H, Mocco J, Siddiqui A, Mandelbaum M, Kolega J, Xiang J, et al. High Wall Shear Stress and Positive Wall Shear Stress Gradient Trigger the Initiation of Intracranial Aneurysms. Am Soc Mech Eng. 2009; : 523-4[DOI]
  • 3. Xiang J, Tutino VM, Snyder KV, Meng H. CFD: Computational fluid dynamics or confounding factor dissemination? The role of hemodynamics in intracranial aneurysm rupture risk assessment. Am J Neuroradiology. 2014; 35(10): 1849-57[DOI]
  • 4. Arzani A, Dyverfeldt P, Ebbers T, Shadden SC. In vivo validation of numerical prediction for turbulence intensity in an aortic coarctation. Ann Biomed Eng. 2012; 40(4): 860-70[DOI][PubMed]
  • 5. Nixon AM, Gunel M, Sumpio BE. The critical role of hemodynamics in the development of cerebral vascular disease. J Neurosurg. 2010; 112(6): 1240-53[DOI][PubMed]
  • 6. Shojima M, Oshima M, Takagi K, Torii R, Hayakawa M, Katada K, et al. Magnitude and role of wall shear stress on cerebral aneurysm: computational fluid dynamic study of 20 middle cerebral artery aneurysms. Stroke. 2004; 35(11): 2500-5[DOI][PubMed]
  • 7. Sforza DM, Putman CM, Cebral JR. Hemodynamics of Cerebral Aneurysms. Annu Rev Fluid Mech. 2009; 41: 91-107[DOI][PubMed]
  • 8. Baek H, Jayaraman MV, Karniadakis GE. Wall shear stress and pressure distribution on aneurysms and infundibulae in the posterior communicating artery bifurcation. Ann Biomed Eng. 2009; 37(12): 2469-87[DOI][PubMed]
  • 9. Mantha A, Karmonik C, Benndorf G, Strother C, Metcalfe R. Hemodynamics in a cerebral artery before and after the formation of an aneurysm. AJNR Am J Neuroradiol. 2006; 27(5): 1113-8[PubMed]
  • 10. Kulcsar Z, Ugron A, Marosfoi M, Berentei Z, Paal G, Szikora I. Hemodynamics of cerebral aneurysm initiation: the role of wall shear stress and spatial wall shear stress gradient. AJNR Am J Neuroradiol. 2011; 32(3): 587-94[DOI][PubMed]
  • 11. Kroon M, Holzapfel GA. Modeling of saccular aneurysm growth in a human middle cerebral artery. J Biomech Eng. 2008; 130(5): 51012[DOI][PubMed]
  • 12. Boussel L, Rayz V, McCulloch C, Martin A, Acevedo-Bolton G, Lawton M, et al. Aneurysm growth occurs at region of low wall shear stress: patient-specific correlation of hemodynamics and growth in a longitudinal study. Stroke. 2008; 39(11): 2997-3002[DOI][PubMed]
  • 13. Jou LD, Lee DH, Morsi H, Mawad ME. Wall shear stress on ruptured and unruptured intracranial aneurysms at the internal carotid artery. AJNR Am J Neuroradiol. 2008; 29(9): 1761-7[DOI][PubMed]
  • 14. Cebral JR, Mut F, Weir J, Putman C. Quantitative characterization of the hemodynamic environment in ruptured and unruptured brain aneurysms. AJNR Am J Neuroradiol. 2011; 32(1): 145-51[DOI][PubMed]
  • 15. Bowker TJ, Watton PN, Summers PE, Byrne JV, Ventikos Y. Rest versus exercise hemodynamics for middle cerebral artery aneurysms: a computational study. AJNR Am J Neuroradiol. 2010; 31(2): 317-23[DOI][PubMed]
  • 16. Les AS, Shadden SC, Figueroa CA, Park JM, Tedesco MM, Herfkens RJ, et al. Quantification of hemodynamics in abdominal aortic aneurysms during rest and exercise using magnetic resonance imaging and computational fluid dynamics. Ann Biomed Eng. 2010; 38(4): 1288-313[DOI][PubMed]
  • 17. Suh GY, Les AS, Tenforde AS, Shadden SC, Spilker RL, Yeung JJ, et al. Hemodynamic changes quantified in abdominal aortic aneurysms with increasing exercise intensity using mr exercise imaging and image-based computational fluid dynamics. Ann Biomed Eng. 2011; 39(8): 2186-202[DOI][PubMed]
  • 18. Nichols WW, O'Rourke MF. McDonald's blood flow in arteries: theoretical, experimental, and clinical principles:. 2011;
  • 19. Humphrey JD, Na S. Elastodynamics and arterial wall stress. Ann Biomed Eng. 2002; 30(4): 509-23[PubMed]
  • 20. Reymond P, Merenda F, Perren F, Rufenacht D, Stergiopulos N. Validation of a one-dimensional model of the systemic arterial tree. Am J Physiol Heart Circ Physiol. 2009; 297(1)-22[DOI][PubMed]
  • 21. Sato K, Sadamoto T. Different blood flow responses to dynamic exercise between internal carotid and vertebral arteries in women. J Appl Physiol (1985). 2010; 109(3): 864-9[DOI][PubMed]
  • 22. Malek AM, Alper SL, Izumo S. Hemodynamic shear stress and its role in atherosclerosis. JAMA. 1999; 282(21): 2035-42[PubMed]
  • 23. Cebral JR, Castro MA, Putman CM, Alperin N. Flow-area relationship in internal carotid and vertebral arteries. Physiol Meas. 2008; 29(5): 585-94[DOI][PubMed]
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