Iranian Journal of Radiology

Published by: Kowsar

Magnetic Resonance Spectroscopic Findings of Chronic Lesions in Two Subtypes of Multiple Sclerosis: Primary Progressive Versus Relapsing Remitting

Nasrin Rahimian 1 , Hamidreza Saligheh Rad 2 , Kavous Firouznia 3 , Seyed Amir Ebrahimzadeh 4 , Alipasha Meysamie 5 , Hamideh Vafaiean 2 and Mohammad Hossein Harirchian 1 , *
Authors Information
1 Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran
2 Quantitative MR Imaging and Spectroscopy Group, Research Center for Cellular and Molecular Imaging, Medical Physics and Biomedical Engineering Department, Tehran University of Medical Sciences, Tehran, Iran
3 Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran
4 Department of Radiology, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5 Community Medicine Department, Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran
Article information
  • Iranian Journal of Radiology: September 01, 2013, 10 (3); 128-132
  • Published Online: August 30, 2013
  • Article Type: Research Article
  • Received: March 8, 2013
  • Revised: April 15, 2013
  • Accepted: May 2, 2013
  • DOI: 10.5812/iranjradiol.11336

To Cite: Rahimian N, Saligheh Rad H, Firouznia K, Ebrahimzadeh S A, Meysamie A, et al. Magnetic Resonance Spectroscopic Findings of Chronic Lesions in Two Subtypes of Multiple Sclerosis: Primary Progressive Versus Relapsing Remitting, Iran J Radiol. 2013 ; 10(3):128-132. doi: 10.5812/iranjradiol.11336.

Copyright © 2013, Tehran University of Medical Sciences and Iranian Society of Radiology. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Compston A\r\nColes. Multiple sclerosis. The Lancet. 2002; 359(9313): 1221-1231[DOI]
  • 2. Thompson AJ\nKermode, et al. Major differences in the dynamics of primary and secondary progressive multiple sclerosis. Ann Neurol. 1991; 29(1): 53-62[DOI][PubMed]
  • 3. Harirchian MH\nRezvanizadeh, et al. Non-invasive brain mapping of motor-related areas of four limbs in patients with clinically isolated syndrome compared to healthy normal controls. J Clin Neurosci. 2010; 17(6): 736-41[DOI][PubMed]
  • 4. Bjartmar C\r\nTrapp. Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences. Curr Opin Neurol. 2001; 14(3): 271-278
  • 5. Barkhof F. The clinico-radiological paradox in multiple sclerosis revisited. Curr Opin Neurol. 2002; 15(3): 239-45[PubMed]
  • 6. Allen IV\r\nMcKeown. A histological, histochemical and biochemical study of the macroscopically normal white matter in multiple sclerosis. J Neurol Sci. 1979; 41(1): 81-91[DOI]
  • 7. Suhy J\nRooney, et al. 1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS. Mult Scler. 2000; 6(3): 148-55[PubMed]
  • 8. Kidd D\nBarker, et al. The transverse magnetisation decay characteristics of longstanding lesions and normal-appearing white matter in multiple sclerosis. J Neurol. 1997; 244(2): 125-30[PubMed]
  • 9. Richards TL. Proton MR spectroscopy in multiple sclerosis: value in establishing diagnosis, monitoring progression, and evaluating therapy. AJR Am J Roentgenol. 1991; 157(5): 1073-8[DOI][PubMed]
  • 10. Ross B\nBluml. Magnetic resonance spectroscopy of the human brain. Anat Rec. 2001; 265(2): 54-84[PubMed]
  • 11. Urenjak J\nWilliams. Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. J Neurosci. 1993; 13(3): 981-9[PubMed]
  • 12. Birken DL\r\nOldendorf. N-Acetyl-L-Aspartic acid: A literature review of a compound prominent in 1H-NMR spectroscopic studies of brain. Neurosci Biobehav Rev. 1989; 13(1): 23-31[DOI]
  • 13. Bitsch A\nBruhn, et al. Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy. AJNR Am J Neuroradiol. 1999; 20(9): 1619-27[PubMed]
  • 14. Caramanos Z\nNarayanan. 1H-MRS quantification of tNA and tCr in patients with multiple sclerosis: a meta-analytic review. Brain. 2005; 128: 2483-506[DOI][PubMed]
  • 15. Narayana PA. Magnetic resonance spectroscopy in the monitoring of multiple sclerosis. J Neuroimaging. 2005; 15(4 Suppl): 46S-57S[DOI][PubMed]
  • 16. Polman CH\nReingold, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria". Ann Neurol. 2005; 58(6): 840-6[DOI][PubMed]
  • 17. Ratiney H\nSdika. Time-domain semi-parametric estimation based on a metabolite basis set. NMR Biomed. 2005; 18(1): 1-13[DOI][PubMed]
  • 18. Bagory M\nDurand-Dubief, et al. Implementation of an absolute brain 1H-MRS quantification method to assess different tissue alterations in multiple sclerosis. IEEE Trans Biomed Eng. 2012; 59(10): 2687-94[DOI][PubMed]
  • 19. Lublin FD\nReingold. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology. 1996; 46(4): 907-11[PubMed]
  • 20. Koopmans RA\nLi. Benign versus chronic progressive multiple sclerosis: magnetic resonance imaging features. Ann Neurol. 1989; 25(1): 74-81[DOI][PubMed]
  • 21. Noseworthy JH\nLucchinetti. Multiple sclerosis. N Engl J Med. 2000; 343(13): 938-52[DOI][PubMed]
  • 22. Trapp BD\nPeterson. Axonal transection in the lesions of multiple sclerosis. N Engl J Med. 1998; 338(5): 278-85[DOI][PubMed]
  • 23. Nijeholt GJ\r\nvan Walderveen, et al. Brain and spinal cord abnormalities in multiple sclerosis. Correlation between MRI parameters, clinical subtypes and symptoms. Brain. 1998; 121: 687-97[PubMed]
  • 24. Davie CA\r\nBarker. 1H magnetic resonance spectroscopy of chronic cerebral white matter lesions and normal appearing white matter in multiple sclerosis. J Neurol Neurosurg Psychiatry. 1997; 63(6): 736-42[PubMed]
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