Iranian Journal of Radiology

Published by: Kowsar

Non-Calcified Coronary Artery Plaque Characterization by Dual-Energy Computed Tomography

Rezvan Ravanfar Haghighi 1 , * , Sabyasachi Chatterjee 2 , Vardahan.C. Vani 3 , Pratik Kumar 4 , Milo Tabin 5 , Ruma Ray 6 , Reza Jalli 1 , Sepide Sefidbakht 1 , Fariba Zarei 1 , Ali Reza Shakibafard 1 , Somayeh Gholami Bardeji 1 , Mahdi Dodangeh 1 and Bijan Bijan 1 , 7
Authors Information
1 Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2 BGVS Chemical Engineering Building (Old), Indian Institute of Science, Bangalore, India
3 Department of Instrumentation and Applied Physics, Indian Institute of Science, Bangalore, India
4 Medical Physics Unit, IRCH, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
5 Department of Forensic Medicine, All India Institute of Medical Sciences, New Delhi, India
6 Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
7 Department of Radiology, Sutter Medical Group/University of California Davis, Sacramento, California, USA
Article information
  • Iranian Journal of Radiology: April 2018, 15 (2); e13970
  • Published Online: February 12, 2018
  • Article Type: Research Article
  • Received: April 5, 2017
  • Revised: October 4, 2017
  • Accepted: October 27, 2017
  • DOI: 10.5812/iranjradiol.13970

To Cite: Ravanfar Haghighi R, Chatterjee S, Vani V, Kumar P, Tabin M, et al. Non-Calcified Coronary Artery Plaque Characterization by Dual-Energy Computed Tomography, Iran J Radiol. 2018 ; 15(2):e13970. doi: 10.5812/iranjradiol.13970.

Copyright © 2018, Iranian Journal of Radiology. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Adiguzel E, Ahmad PJ, Franco C, Bendeck MP. Collagens in the progression and complications of atherosclerosis. Vasc Med. 2009;14(1):73-89. doi: 10.1177/1358863X08094801. [PubMed: 19144782].
  • 2. Greenland P, Smith SJ, Grundy SM. Improving coronary heart disease risk assessment in asymptomatic people: role of traditional risk factors and noninvasive cardiovascular tests. Circulation. 2001;104(15):1863-7. [PubMed: 11591627].
  • 3. Fuster V, Fayad ZA, Badimon JJ. Acute coronary syndromes. Biolog Lancet. 1999;353:s5-9.
  • 4. Nair A, Kuban BD, Tuzcu EM, Schoenhagen P, Nissen SE, Vince DG. Coronary plaque classification with intravascular ultrasound radiofrequency data analysis. Circulation. 2002;106(17):2200-6. [PubMed: 12390948].
  • 5. Kume T, Akasaka T, Kawamoto T, Watanabe N, Toyota E, Neishi Y, et al. Assessment of coronary arterial plaque by optical coherence tomography. Am J Cardiol. 2006;97(8):1172-5. doi: 10.1016/j.amjcard.2005.11.035. [PubMed: 16616021].
  • 6. Vaina S, Stefanadis C. Detection of the vulnerable coronary atheromatous plaque. Where are we now? Int J Cardiovasc Intervent. 2005;7(2):75-87. doi: 10.1080/14628840510011252. [PubMed: 16093216].
  • 7. Boll DT, Hoffmann MH, Huber N, Bossert AS, Aschoff AJ, Fleiter TR. Spectral coronary multidetector computed tomography angiography: dual benefit by facilitating plaque characterization and enhancing lumen depiction. J Comput Assist Tomogr. 2006;30(5):804-11. doi: 10.1097/01.rct.0000228162.70849.26. [PubMed: 16954934].
  • 8. Horiguchi J, Fujioka C, Kiguchi M, Shen Y, Althoff CE, Yamamoto H, et al. Soft and intermediate plaques in coronary arteries: how accurately can we measure CT attenuation using 64-MDCT? AJR Am J Roentgenol. 2007;189(4):981-8. doi: 10.2214/AJR.07.2296. [PubMed: 17885074].
  • 9. Kramer CM, Anderson JD. MRI of atherosclerosis: diagnosis and monitoring therapy. Expert Rev Cardiovasc Ther. 2007;5(1):69-80. doi: 10.1586/14779072.5.1.69. [PubMed: 17187458].
  • 10. Schnapauff D, Zimmermann E, Dewey M. Technical and clinical aspects of coronary computed tomography angiography. Semin Ultrasound CT MRI. 2008;29(3):167-75.
  • 11. Schneider W, Bortfeld T, Schlegel W. Correlation between CT numbers and tissue parameters needed for Monte Carlo simulations of clinical dose distributions. Physic Med Biolog. 2000;45(2):459-78.
  • 12. Cademartiri F, La Grutta L, Palumbo AA, Maffei E, Runza G, Bartolotta TV, et al. Coronary plaque imaging with multislice computed tomography: technique and clinical applications. Europ Radiol Suppl. 2006;16(7):M44-53.
  • 13. Macovski A, Alvarez RE, Chan JLH, Stonestrom JP, Zatz LM. Energy dependent reconstruction in X-ray computerized tomography. Comput Biol Med. 1976;6(4):325IN7335-334336.
  • 14. Rutherford RA, Pullan BR, Isherwood I. Measurement of effective atomic number and electron density using an EMI scanner. Neuroradiology. 1976;11(1):15-21. [PubMed: 934468].
  • 15. Chiro GD, Brooks RA, Kessler RM, Johnston GS, Jones AE, Herdt JR, et al. Tissue signatures with dual-energy computed tomography. Radiology. 1979;131(2):521-3. doi: 10.1148/131.2.521. [PubMed: 441344].
  • 16. Heismann BJ, Leppert J, Stierstorfer K. Density and atomic number measurements with spectral x-ray attenuation method. J Appl Physic. 2003;94(3):2073-9.
  • 17. Johnson TR, Krauss B, Sedlmair M, Grasruck M, Bruder H, Morhard D, et al. Material differentiation by dual energy CT: initial experience. Eur Radiol. 2007;17(6):1510-7. doi: 10.1007/s00330-006-0517-6. [PubMed: 17151859].
  • 18. Tanami Y, Ikeda E, Jinzaki M, Satoh K, Nishiwaki Y, Yamada M, et al. Computed tomographic attenuation value of coronary atherosclerotic plaques with different tube voltage: an ex vivo study. J Comput Assist Tomogr. 2010;34(1):58-63. doi: 10.1097/RCT.0b013e3181b66c41. [PubMed: 20118723].
  • 19. Haghighi RR, Chatterjee S, Tabin M, Sharma S, Jagia P, Ray R, et al. DECT evaluation of noncalcified coronary artery plaque. Med Phys. 2015;42(10):5945-54. doi: 10.1118/1.4929935. [PubMed: 26429269].
  • 20. Haghighi RR, Chatterjee S, Vyas A, Kumar P, Thulkar S. X-ray attenuation coefficient of mixtures: inputs for dual-energy CT. Med Phys. 2011;38(10):5270-9. doi: 10.1118/1.3626572. [PubMed: 21992344].
  • 21. Okayama S, Soeda T, Takami Y, Kawakami R, Somekawa S, Uemura S, et al. The influence of effective energy on computed tomography number depends on tissue characteristics in monoenergetic cardiac imaging. Radiol Res Pract. 2012;2012.
  • 22. Van den Berg AA, Van Buul JD, Tytgat GNJ, Groen AK, Ostrow JD. Mucins and calcium phosphate precipitates additively stimulate cholesterol crystallization. J Lipid Res. 1998;39(9):1744-51.
  • 23. Vedre A, Pathak DR, Crimp M, Lum C, Koochesfahani M, Abela GS. Physical factors that trigger cholesterol crystallization leading to plaque rupture. Atherosclerosis. 2009;203(1):89-96. doi: 10.1016/j.atherosclerosis.2008.06.027. [PubMed: 18703195].
  • 24. Srinivasan A, Ramaswamy V, Kuruvilla S, Sehgal PK, Balakrishnan K. Calcified atherosclerotic plaque-where exactly is the calcium and what does it contain? India J Thorac Cardiovasc Surg. 2012;28(1):6-14.
  • 25. Becker CR, Nikolaou K, Muders M, Babaryka G, Crispin A, Schoepf UJ, et al. Ex vivo coronary atherosclerotic plaque characterization with multi-detector-row CT. Eur Radiol. 2003;13(9):2094-8. doi: 10.1007/s00330-003-1889-5. [PubMed: 12692681].
  • 26. Haghighi RR, Chatterjee S, Kumar P, Chatterjee V. Numerical Analysis of the Relationship between the Photoelectric Effect and Energy of the X-Ray Photons in CT. Front Biomed Technol. 2015;1(4):240-51.
  • 27. Hubbell JH, Seltzer SM. Table of X-ray mass attenuation coefficients from 1 keV to 20 MeV for elements Z = 1 to 92 and 48 additional substances of dosimetric interest. 05 Apr 2017. Available from:

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