Iranian Journal of Radiology

Published by: Kowsar

99mTc-HMPAO-Labeled Autologous Leukocyte SPECT/CT for Diagnosis of Bacterial Endocarditis of the Prosthetic Pulmonary Conduit: A Clinical Case

Svetlana Ivanovna Sazonova 1 , 2 , Julia Nikolaevna Ilyushenkova 1 , 2 , * , Konstantin Valer’evich Zavadovsky 1 , 2 and Yuri Borisovich Lishmanov 1 , 2
Authors Information
1 Nuclear Medicine Department, Federal State Budgetary Scientific Institution, Research Institute for Cardiology, Russia
2 Laboratory No. 31, National Research Tomsk Polytechnic University, Russia
Article information
  • Iranian Journal of Radiology: January 2017, 14 (1); e13472
  • Published Online: June 19, 2016
  • Article Type: Case Report
  • Received: October 26, 2015
  • Revised: December 11, 2015
  • Accepted: December 16, 2015
  • DOI: 10.5812/iranjradiol.34073

To Cite: Sazonova S I, Nikolaevna Ilyushenkova J, Valer’evich Zavadovsky K, Borisovich Lishmanov Y. 99mTc-HMPAO-Labeled Autologous Leukocyte SPECT/CT for Diagnosis of Bacterial Endocarditis of the Prosthetic Pulmonary Conduit: A Clinical Case, Iran J Radiol. 2017 ; 14(1):e13472. doi: 10.5812/iranjradiol.34073.

Copyright © 2016, Tehran University of Medical Sciences and Iranian Society of Radiology. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Case Presentation
3. Discussion
  • 1. Prendergast BD, Tornos P. Surgery for infective endocarditis: who and when? Circulation. 2010; 121(9): 1141-52[DOI][PubMed]
  • 2. Westphal N, Plicht B, Naber C. Infective endocarditis--prophylaxis, diagnostic criteria, and treatment. Dtsch Arztebl Int. 2009; 106(28-29): 481-9[DOI][PubMed]
  • 3. Roca M, de Vries E, Jamar F, Israel O, Signore A. Guidelines for the labelling of leucocytes with 111In-oxine. ‎Eur J Nucl Med Mol. 2010; 37(4): 835-41
  • 4. Yamamoto T, Yodogawa K, Wakita S, Ogano M, Tokita M, Miyagi Y, et al. Recurrent prosthetic valve endocarditis caused by Staphylococcus aureus colonizing skin lesions in severe atopic dermatitis. Inter Med. 2007; 46(9): 571-3
  • 5. Iung B, Erba PA, Petrosillo N, Lazzeri E. Common diagnostic flowcharts in infective endocarditis. Q J Nucl Med Mol Imaging. 2014; 58(1): 55-65[PubMed]
  • 6. Li JS, Sexton DJ, Mick N, Nettles R, Fowler VJ, Ryan T, et al. Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis. 2000; 30(4): 633-8[DOI][PubMed]
  • 7. Thuny F, Grisoli D, Collart F, Habib G, Raoult D. Management of infective endocarditis: challenges and perspectives. Lancet. 2012; 379(9819): 965-75[DOI][PubMed]
  • 8. Purnell GL, Walker CW, Allison JW, Dalrymple GV. Indium-111 leukocyte localization in infected prosthetic graft. Clin Nucl Med. 1990; 15(8): 585-6[PubMed]
  • 9. Thomson LE, Goodman MP, Naqvi TZ, Feldman R, Buchbinder NA, Waxman A, et al. Aortic root infection in a prosthetic valve demonstrated by gallium-67 citrate SPECT. Clin Nucl Med. 2005; 30(4): 265-8[PubMed]
  • 10. Yavari A, Ayoub T, Livieratos L, Raman V, McWilliams ET. Diagnosis of prosthetic aortic valve endocarditis with gallium-67 citrate single-photon emission computed tomography/computed tomography hybrid imaging using software registration. Circ Cardiovasc Imaging. 2009; 2(6)-3[DOI][PubMed]
  • 11. Hyafil F, Rouzet F, Lepage L, Benali K, Raffoul R, Duval X, et al. Role of radiolabelled leucocyte scintigraphy in patients with a suspicion of prosthetic valve endocarditis and inconclusive echocardiography. Eur Heart J Cardiovasc Imaging. 2013; 14(6): 586-94[DOI][PubMed]
  • 12. Sazonova SI, Proskokova I, Guseva AM, Konkovskaia Iu A, Garganeeva AA, Suslova TE, et al. [Radionuclide methods for diagnostics of non-rheumatic myocarditis and postmyocarditic cardiosclerosis]. Klin Med (Mosk). 2011; 89(2): 32-5[PubMed]
  • 13. Majmudar MD, Nahrendorf M. Cardiovascular molecular imaging: the road ahead. J Nucl Med. 2012; 53(5): 673-6[DOI][PubMed]
  • 14. Kramer CM, Sinusas AJ, Sosnovik DE, French BA, Bengel FM. Multimodality imaging of myocardial injury and remodeling. J Nucl Med. 2010; 51 Suppl 1: 107S-21S[DOI][PubMed]
  • 15. Prior JO, Farhad H, Muller O. Multimodality Imaging in Ischemic Cardiomyopathy. Curr Cardiovasc Imaging Rep. 2014; 7: 9285[DOI][PubMed]
  • 16. Erba PA, Sollini M, Conti U, Bandera F, Tascini C, De Tommasi SM, et al. Radiolabeled WBC scintigraphy in the diagnostic workup of patients with suspected device-related infections. JACC Cardiovasc Imaging. 2013; 6(10): 1075-86[DOI][PubMed]
  • 17. Erba PA, Conti U, Lazzeri E, Sollini M, Doria R, De Tommasi SM, et al. Added value of 99mTc-HMPAO-labeled leukocyte SPECT/CT in the characterization and management of patients with infectious endocarditis. J Nucl Med. 2012; 53(8): 1235-43[DOI][PubMed]
  • 18. Kostkiewicz M. 99mTc-HMPAO labeled leukocyte SPECT/CT in evaluation of infective endocarditis inflammatory processes. Eur Heart J Cardiovasc Imaging. 2015; -28
  • 19. Bruun NE, Habib G, Thuny F, Sogaard P. Cardiac imaging in infectious endocarditis. Eur Heart J. 2014; 35(10): 624-32[DOI][PubMed]
  • 20. Tanis W, Scholtens A, Habets J, van den Brink RB, van Herwerden LA, Chamuleau SA, et al. Positron emission tomography/computed tomography for diagnosis of prosthetic valve endocarditis: increased valvular 18F-fluorodeoxyglucose uptake as a novel major criterion. J Am Coll Cardiol. 2014; 63(2): 186-7[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments