Iranian Journal of Radiology

Published by: Kowsar

Magnetic Resonance Spectroscopy of Brain Circuits in Patients with First-Episode Obsessive-Compulsive Disorder

Feng Chen 1 , Min Guo 2 , * , Tao Liu 3 , Xiang Ling Jiang 2 , Jian Jun Li 1 and Jun Cheng Guo 2
Authors Information
1 Department of Radiology, Hainan General Hospital, Haikou, China
2 Psychological Research Center, Hainan General Hospital, Haikou, China
3 Department of Neurology, Hainan General Hospital, Haikou, China
Article information
  • Iranian Journal of Radiology: January 2017, 14 (1); e13452
  • Published Online: August 7, 2016
  • Article Type: Research Article
  • Received: October 23, 2013
  • Revised: September 10, 2014
  • Accepted: December 3, 2014
  • DOI: 10.5812/iranjradiol.15566

To Cite: Chen F, Guo M, Liu T, Jiang X L, Li J J, et al. Magnetic Resonance Spectroscopy of Brain Circuits in Patients with First-Episode Obsessive-Compulsive Disorder, Iran J Radiol. 2017 ; 14(1):e13452. doi: 10.5812/iranjradiol.15566.

Copyright © 2016, Tehran University of Medical Sciences and Iranian Society of Radiology. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Menzies L, Chamberlain SR, Laird AR, Thelen SM, Sahakian BJ, Bullmore ET. Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited. Neurosci Biobehav Rev. 2008; 32(3): 525-49[DOI][PubMed]
  • 2. Hagen K, Hansen B, Joa I, Larsen TK. Prevalence and clinical characteristics of patients with obsessive-compulsive disorder in first-episode psychosis. BMC Psychiatry. 2013; 13: 156[DOI][PubMed]
  • 3. Whiteside SP, Abramowitz JS, Port JD. Decreased caudate N-acetyl-l-aspartic acid in pediatric obsessive-compulsive disorder and the effects of behavior therapy. Psychiatry Res. 2012; 202(1): 53-9[DOI][PubMed]
  • 4. Poyurovsky M, Faragian S, Pashinian A, Levi A, Viosburd A, Stryjer R, et al. Neurological soft signs in schizophrenia patients with obsessive-compulsive disorder. J Neuropsychiatry Clin Neurosci. 2007; 19(2): 145-50[DOI][PubMed]
  • 5. Murayama K, Nakao T, Kanba S. [Neuro-pathophysiological hypothesis of obsessive compulsive disorder based on the findings from neuroimaging studies]. Fukuoka Igaku Zasshi. 2013; 104(5): 81-8[PubMed]
  • 6. Cavedini P, Zorzi C, Piccinni M, Cavallini MC, Bellodi L. Executive dysfunctions in obsessive-compulsive patients and unaffected relatives: searching for a new intermediate phenotype. Biol Psychiatry. 2010; 67(12): 1178-84[DOI][PubMed]
  • 7. Schiepek G, Tominschek I, Karch S, Mulert C, Pogarell O. [Neuroimaging and the neurobiology of obsessive-compulsive disorder]. Psychother Psychosom Med Psychol. 2007; 57(9-10): 379-94[DOI][PubMed]
  • 8. Del Casale A, Kotzalidis GD, Rapinesi C, Serata D, Ambrosi E, Simonetti A, et al. Functional neuroimaging in obsessive-compulsive disorder. Neuropsychobiology. 2011; 64(2): 61-85[DOI][PubMed]
  • 9. Kwon JS, Jang JH, Choi JS, Kang DH. Neuroimaging in obsessive-compulsive disorder. Expert Rev Neurother. 2009; 9(2): 255-69[DOI][PubMed]
  • 10. Atmaca M, Yildirim H, Ozdemir H, Tezcan E, Poyraz AK. Volumetric MRI study of key brain regions implicated in obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2007; 31(1): 46-52[DOI][PubMed]
  • 11. Karlas T, Petroff D, Garnov N, Bohm S, Tenckhoff H, Wittekind C, et al. Non-invasive assessment of hepatic steatosis in patients with NAFLD using controlled attenuation parameter and 1H-MR spectroscopy. PLoS One. 2014; 9(3): 91987[DOI][PubMed]
  • 12. Lapidus KA, Gabbay V, Mao X, Johnson A, Murrough JW, Mathew SJ, et al. In vivo (1)H MRS study of potential associations between glutathione, oxidative stress and anhedonia in major depressive disorder. Neurosci Lett. 2014; 569: 74-9[DOI][PubMed]
  • 13. Lazaro L, Bargallo N, Andres S, Falcon C, Morer A, Junque C, et al. Proton magnetic resonance spectroscopy in pediatric obsessive-compulsive disorder: longitudinal study before and after treatment. Psychiatry Res. 2012; 201(1): 17-24[DOI][PubMed]
  • 14. O'Neill J, Piacentini JC, Chang S, Levitt JG, Rozenman M, Bergman L, et al. MRSI correlates of cognitive-behavioral therapy in pediatric obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2012; 36(1): 161-8[DOI][PubMed]
  • 15. Bartha R, Stein MB, Williamson PC, Drost DJ, Neufeld RW, Carr TJ, et al. A short echo 1H spectroscopy and volumetric MRI study of the corpus striatum in patients with obsessive-compulsive disorder and comparison subjects. Am J Psychiatry. 1998; 155(11): 1584-91[DOI][PubMed]
  • 16. Fitzgerald KD, Moore GJ, Paulson LA, Stewart CM, Rosenberg DR. Proton spectroscopic imaging of the thalamus in treatment-naive pediatric obsessive-compulsive disorder. Biol Psychiatr. 2000; 47(3): 174-82
  • 17. Olvera RL, Caetano SC, Stanley JA, Chen HH, Nicoletti M, Hatch JP, et al. Reduced medial prefrontal N-acetyl-aspartate levels in pediatric major depressive disorder: a multi-voxel in vivo(1)H spectroscopy study. Psychiatry Res. 2010; 184(2): 71-6[DOI][PubMed]
  • 18. Russell A, Cortese B, Lorch E, Ivey J, Banerjee SP, Moore GJ, et al. Localized functional neurochemical marker abnormalities in dorsolateral prefrontal cortex in pediatric obsessive-compulsive disorder. J Child Adolesc Psychopharmacol. 2003; 13 Suppl 1: 31-8[DOI][PubMed]
  • 19. Whiteside SP, Port JD, Deacon BJ, Abramowitz JS. A magnetic resonance spectroscopy investigation of obsessive-compulsive disorder and anxiety. Psychiatry Res. 2006; 146(2): 137-47[DOI][PubMed]
  • 20. Fan Q, Tan L, You C, Wang J, Ross CA, Wang X, et al. Increased N-Acetylaspartate/creatine ratio in the medial prefrontal cortex among unmedicated obsessive-compulsive disorder patients. Psychiatry Clin Neurosci. 2010; 64(5): 483-90[DOI][PubMed]
  • 21. Bedard MJ, Chantal S. Brain magnetic resonance spectroscopy in obsessive-compulsive disorder: the importance of considering subclinical symptoms of anxiety and depression. Psychiatry Res. 2011; 192(1): 45-54[DOI][PubMed]
  • 22. Starck G, Ljungberg M, Nilsson M, Jonsson L, Lundberg S, Ivarsson T, et al. A 1H magnetic resonance spectroscopy study in adults with obsessive compulsive disorder: relationship between metabolite concentrations and symptom severity. J Neural Transm (Vienna). 2008; 115(7): 1051-62[DOI][PubMed]
  • 23. Jang JH, Kwon JS, Jang DP, Moon WJ, Lee JM, Ha TH, et al. A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive-compulsive disorder. Am J Psychiatry. 2006; 163(7): 1202-7[DOI][PubMed]
  • 24. Mohamed MA, Smith MA, Schlund MW, Nestadt G, Barker PB, Hoehn-Saric R. Proton magnetic resonance spectroscopy in obsessive-compulsive disorder: a pilot investigation comparing treatment responders and non-responders. Psychiatry Res. 2007; 156(2): 175-9[DOI][PubMed]
  • 25. Shin LM, Davis FC, Vanelzakker MB, Dahlgren MK, Dubois SJ. Neuroimaging predictors of treatment response in anxiety disorders. Biol Mood Anxiety Disord. 2013; 3(1): 15[DOI][PubMed]
  • 26. Brennan BP, Rauch SL, Jensen JE, Pope HG. A critical review of magnetic resonance spectroscopy studies of obsessive-compulsive disorder. Biol Psychiatry. 2013; 73(1): 24-31[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments